Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE ROLE OF NITRIC OXIDE AND PEROXYNITRITE IN THE DEVELOPMENT OF PERINATAL HYPOXIC-ISCHEMIC CNS LESIONS IN NEWBORNS

Afonin A.A. 1 Loginova I.G. 1 Drukker N.A. 1
1 FGSFO «Scientific-research Institute of obstetrics and Pediatrics» the Ministry of Health of the Russian Federation
Represents the results of a comprehensive survey of 60 children in the first three months of life. Depending on the presence and severity of perinatal lesions of the central nervous system all infants were divided into 3 groups. Evaluates performance of ultrasound scanning of the brain, and the content of some derivatives of L-arginine (nitric oxide, NO-synthase, peroxynitrite) in the blood serum of children observed. There were significant differences between production of nitric oxide, NO-synthase activity and peroxynitrite in children with disorders of the central nervous system in comparison with the control values​​. These changes are the basis of the formation of perinatal CNS lesions, which can be regarded not only as markers of early diagnosis of perinatal brain injury, but also as a criterion of adequacy of therapy.