Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ERYTHROPOIETIN LEVEL AND IMMUNE STATUS IN PATIENTS WITH CHRONIC RENAL FAILURE ON HEMODIALYSIS

Osikov M.V. 1 Telesheva L.F. 1 Ageev Y.I. 1 Fedosov A.A. 1
1 South Ural State Medical University of Health Ministry of Russia
The paper provides information about the study performed on 37 patients with end-stage renal disease (ESRD) undergoing renal replacement therapy by hemodialysis in Chelyabinsk Regional Hospital dialysis unit on 4008S/BIBAG “Artificial kidney” devices of «Fresenius» company (Germany) 3 times a week for 4 hours. Clinically healthy individuals - volunteers without physical illnesses and matched by age and sex with main group (n = 12) were enrolled in the control group. Recombinant human erythropoietin (EPO) was injected to patients with chronic renal failure at a dose of 2000-4000 IU 2 times a week for at least two months prior to the study. Leukocyte count and differential blood count, absorption capacity, oxygen-dependent metabolism and the intensity of the luminescence of the lysosomes of phagocytes, population and subpopulations range of lymphocytes (CD3 +, CD4 +, CD8 +, CD16 +, CD20 +, CD25 +), immunoglobulin level IgA, IgM, IgG, EPO level were counted in the peripheral blood before and after hemodialysis. The study revealed activation of effectors of innate immunity showing the increase of absorbency activity and oxygen-dependent metabolism, decreased level of T-lymphocytes and their subpopulations, B- lymphocytes, NK-cells, activated lymphocytes in peripheral blood and increased levels of immunoglobulins M and G in patients with chronic renal failure. In interdialysis period serum EPO concentration in patients with ESRD is reduced but remains at a level sufficient to adjust the level of red blood cells and hemoglobin in blood. By means of correlation analysis the reduction of populations and subpopulations of lymphocytes was revealed to increase in the blood of patients with chronic renal failure while the concentration of serum EPO was decreased.