Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE MARKERS OF FIBROSIS IN PATIENTS WITH ATRIAL FIBRILLATION AND ARTERIAL HYPERTENSION

Ratanova E.A. 1 Grigoriadi N.E. 2 Vasilez L.M. 1 Karpunina N.S. 1 Petrusha A.V. 1 Krivaya A.A. 1 Tuev A.V. 1
1 PGMA Perm
2 Perm regional hospital
The indicators of cardiac fibrosis at patients with various forms of atrial fibrillation (recidivous, permanent) were investigated. The study included patients with different forms of atrial fibrillation in combination with arterial hypertension and without it. Patients of all groups reliably differed from the control group on the level of carboxyterminal propeptid collagen type I (PICP). The level of PICP in patients with arterial hypertension associated with atrial fibrillation (AF) significantly higher than without it. In patients with the permanent atrial fibrillation and isolated arterial hypertension the values of PICP higher than in the recurrent atrial fibrillation , and the concentration of tissue inhibitor of metalloproteinase-1 has a tendency to decrease in the group of the patients with the permanent AF. The level of PICP concentration increases with «idiopathic» atrial fibrillation. The indicators of fibrosis of the myocardium differ on the form of atrial fibrillation and the association with the arterial hypertension.