Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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CHANGE OF THE CYTOKINESS PROFILE AS THE ADAPTATION MECHANISM AT DYSPLASIA OF CONNECTIVE TISSUE

Anikin V.V. 1 Beganskaya N.S. 1
1 Tver State Medical Academy
Research of some indicators of a cytokines´s profile at 62 patients with dysplasia of connective tissue (DST) on an example of a mitral valve prolapse (MVP) diagnosed by clinical and echocardiographic data is carried out. Studied cytokines (interleukin-6, interleukin-10) in serum of blood determined by a method of the immune-enzyme assay by a set “Cytokin» (Russia). It is established that 38,7 % surveyed have a raised serum level of interleukin-10, and at a combination of MVP to other small anomalies of heart its content in serum of blood exceeded control values in 1,4 times (p<0,05). Besides, level interleykin-10 in serum of blood decreased with reduction of frequency of incidence of acute respiratory virus infections of patients with MVP (p<0,05), and with increase in degree of a prolapse of the mitral valve is revealed by a tendency of increase of the contents of this anti-inflammatory cytokin (p<0,05). On the basis of the received data it is possible to assume that increase of concentration anti-inflammatory cytokin IL-10 has adaptive character and is, probably, adaptive mechanism of regulation of immune violations and intercellular interactions as attempt to suppress inflammatory process mesenchymal and infectional character.

Библиографическая ссылка

Аникин В.В., Беганская Н.С. ИЗМЕНЕНИЕ ЦИТОКИНОВОГО ПРОФИЛЯ КАК МЕХАНИЗМ АДАПТАЦИИ ПРИ СОЕДИНИТЕЛЬНОТКАННОЙ ДИСПЛАЗИИ // Научное обозрение. Медицинские науки. 2014. № 1. С. 28-28;
URL: https://science-medicine.ru/en/article/view?id=11 (дата обращения: 25.05.2026).