Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

Personal portfolio

ROLE OF INNATE IMMUNITY RECEPTORS IN THE PATHOGENESIS OF BURN DISEASE

Gordinskaya N.A. 1 Aleinik D.Y. 1 Rubtsova Y.P. 1 Charykova I.N. 1 Frolov A.P. 1
1 Federal State Budgetary Institution “Nizhny Novgorod Research Institute of Traumatology and Orthopedics” of the Ministry of Health of the Russian Federation
This research analyzes expression of Toll-like receptors (TLR2 and TLR4) on CD14+ peripheral blood cells and evaluates their functional activity in patients with severe thermal injuries in the acute period of burn disease. TLR2 expression increase and TLR4 expression decrease (p<0,05) was detected. Medium intensity of fluorescence for TLR2 and TLR4 in patients with severe burns was truly lower than in donors. Decrease in functional activity of TLRs after burn was observed. Production of TNF alpha by mononuclear cells with the use of TLR2 ligand (peptidoglycane) and TLR4 ligand (lipopolyssacharide) was truly lower in patients with thermal injuries than in donor group, which may be the cause for weakening of protective functions in burn infection development.