Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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TRANSCAPILLAR LIQUID EXCHANGE AND OXYGENATION FUNCTION OF LUNGS AT VARIOUS MODIFICATIONS OF ANTIBIOTIC TARGETED TRANSPORT

Gurevich K.G. 1 Levina T.M. 2 Pyataev N.A. 2
1 Moscow State University of Medicine and Dentistry
2 Ogarev Mordovia State University
In the experiment on 30 rabbits, there have been studied the changes of transcapillar liquid exchange, lung tissue air saturation, and lung oxygenation function at various modifications of cefotataxim and erythromycine directed transport. Et has been sound that the reinfusion of autoerythrocytes treated extracorporally by erythromycine and cefotaxim in a dose of 10,5 • 109 cell/kg does not result in considerable changes in transcapillar liquid exchange in the lung tissue and in its air saturation as compared to a standard antibiotic intravenous injection (control grupp) and does not impair the lung oxygenation function. An increase in the number of cell carriers up to 32,7 • 109 cell/kg is accompanied by impairments in lung diffusion ability (hypoxemia and increase in intralung shunting) by a decrease in lung tissue air saturation by 20,6 %, and by an increase up to 11,5 % in the total volume of liquid in the lungs (mostly due to interstitial liquid the level of which grows up to 52,7 %) as compared to analogous indexes of the control group.