Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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SOME FEATURES OF THE SERINE PROTEASES AND SERPINS IN PATIENTS WITH NASOPHARYNGEAL CANCER RADIATION TREATMENT

Dzhabarov F.R. 1 Rozenko L.Y. 1 Frantsiyants E.M. 1 Kozlova L.S. 1 Kolycheva E.V. 1
1 Federal State Institution “Rostov Cancer Research Institute” of the Ministry of Health of the Russian Federation
To evaluate the results of radiation treatment of patients with nasopharyngeal mode accelerated hyperfractionated and standard fractionation in accordance with the state of proteases and inhibitors that interact with them, in the dynamics of treatment. Materials and methods. Investigated the blood plasma of patients with nasopharyngeal carcinoma treated with standard fractionation and hyperfractionated accelerated mode before treatment, on completion of the course and one month after radiotherapy. Determined by the activity of kallikrein, prekallikrein content, kininrazrushayuschego enzyme, and serine proteases without kallikrein. Results. Clinically, the best results in the group with accelerated hyperfractionated support restoring balance in proteases and maintained at a physiological level throughout the study period. Relatively worse outcomes in the standard fractionation radiotherapy reflected in disequilibrium-proteinase inhibitor system. Conclusion. Activation of protective and adaptive properties of the kallikrein-kinin system in patients receiving remote gamma-therapy during fast fraktsioniovaniya explains a good tolerability and relatively better outcomes.