Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE ROLE OF GENE POLYMORPHISMVASCULAR ENDOTHELIALGROWTH FACTORIN THE DEVELOPMENT OF JUVENILE HEMANGIOMAS

Dubenskiy V.V. 1 Kornusho E.M. 1 Tumanova K.O. 1
1 Tver state medical academy
Juvenile hemangiomas (Hemangioma of infants) is a common congenital vascular tumour identified by 2–10 % of newborns. The reason development of Hemangioma may be a mutation in chromosome sections responsible for education as factors of growth, and the resulting violation of synthesis of regulatory molecules in interaction between growth factors and cells of the blood vessels, thereby changing the answer cells on the impact of enabling or inhibiting angiogenesis factors. Polymorphism at position - 634 c/G gene of vascular cells growth increases activity allele with bubble promoters were associated with increased expression of that factor. To study the role of VEGF gene polymorphism detection -634 C/G in the formation of juvenile hemangiomas. Two groups of children were examined for 30 people each (with juvenile hemangiomas and healthy). Material for the study were obtained from the epithelial cells of the regimens using buccalsoskobe. Pinpoint polymorphism VEGF -634 the minisequesterings reactions were followed by analysis of the products by MALDI-TOF-mass spectrometer. The results of the study indicate that the gene polymorphism of vascular cells growth factor VEGF -634 C/G increases the risk of juvenile hemangiomas in 18 times, compared to the genotype G/G, that allows to consider the availability of point C/G polymorphism VEGF -634 genetic determinant in the development of juvenile hemangiomas.