Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE INFLUENCE OF VEGETATIVE NERVOUS SYSTEM ON THE FORMATION OF ENDOTHELIAL DYSFUNCTION IN HELICOBACTER PYLORI-INFECTED CHILDREN WITH CHRONIC INFLAMMATORY PATHOLOGY OF UPPER PARTS OF ALIMENTARY TRACT IN THE PERIOD OF PUBERTY

Dudnikova E.V. 1 Panova I.V. 1
1 Rostov State Medical University
Investigated the levels of nitric oxide metabolites and endothelin-1 in 77 children in the period of puberty with chronic gastroduodenitis in conjunction with gastroesophageal reflux disease depending on the vegetative regulation and Helicobacter pylori infection. Study of nitric oxide metabolites and endothelin-1 in blood serum was carried out by means of immune-enzyme assay. Diagnosis of Helicobacter pylori was performed by polymerase chain reaction for the detection of Helicobacter pylori DNA in tissue samples antral mucosa of the stomach, urease the method with the definition for estimation of urease activity in biopsy of the mucous membrane of the stomach and immuno-analysis of blood serum for the presence of total antibodies to Helicobacter pylori. The work showed a reduction in the level of nitric oxide metabolites in Helicobacter pylori-positive seropositive patients with the prevalence ofvagotonia. Not found significant differences changes in the level of endothelin-1 depending on the vegetative regulation.