Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE ACTIVITIES OF PURINE METABOLISM ENZYMES IN BLOOD PLASMA OF PATIENTS WITH SERONEGATIVE SPONDYLOARTHRITIS

Evdokimova E.V. 1 Zborovsky A.B. 1 Mozgovaya E.E. 1 Stazharov M.Y. 1 Bedina S.A. 1 Martemyanov V.F. 1
1 Federal State Budgetary Institution « Research Institute of Clinical and Experimental Rheumatology» under the Russian Academy of Medical Sciences (400138
Guanine deaminase (GDA) guanosine deaminase (GSDA), purine nucleoside phosphorylase (PNP), guanosine phosphorylase (GP) activities were determined in blood plasma of 54 patients with reactive arthritis, 55 patients with ankylosing spondylitis and 15 patients with psoriatic arthritis. GDA, PNP activities were higher, GSDA, GP were lower in reactive arthritis patients in comparison with healthy people. GDA, PNP, GP activities were higher and GSDA activity was lower in ankylosing spondylitis patients in comparison with healthy people. The activities of all enzymes were higher in psoriatic arthritis patients in comparison with healthy people. The increase of the pathological process activity was accompanied by the increase of GDA activity , the decrease of GSDA and GP activities in reactive arthritis patients; the increase of GDA, PNP, GP activities, decrease of GSDA activity in ankylosing spondylitis pat ients; the increase the activities of all enzymes in psoriatic arthritis patients. The essential enzyme differences were revealed between all activity degrees of the diseases. GDA, PNP, GP activities were lower and GSDA activity was higher in reactive arthritis patients in comparison with ankylosing spondylitis patients. GDA, PNP, GSDA, GP activities were lower in reactive arthritis patients in comparison with psoriatic arthritis patients. GDA, GSDA activities were lower and GP activity was higher in ankylosing spondylitis patients in comparison with psoriatic arthritis patients. The definition of GDA, PNP, GSDA, GP activities in blood plasma helps to diagnose the degree of the pathological process activity and differentiation of these diseases.