Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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MECHANISMS OF HPRS PATHOGENESIS ARE CAUSED BY THE HEAT SHOCK PROTEIN HSP-70 AND AUTOANTIBODIES TO IT

Egorova E.V. 1 Perestoronin V.I. 1 Tsybikov N.N. 1
1 Chita State Medical Academy
In healthy individuals and patients with chronic purulent rhinosinusitis (HPRS) the level of heat shock protein (HSP-70), and antibodies to it in serum and nasal secretions. Determination was carried out before and after treatment of the original proposed method, based on a preliminary extracorporeal activation of autoleukocytes. It was found that both the stress proteins and autoantibodies to it are defined at a high concentration in healthy and HPRS. In conventional therapy HSP-70 content in the blood serum is increased by 2.6 times, and in nasal secretions in 4 times. After therapy “original” concentration of HSP -70 increases significantly, both in serum (9 times), and nasal secretions (15 times). Also identified changes of the content of autoantibodies HSP-70 in serum: after treatment with the traditional way the level of AAB decreased by 1.8 times, during the original treatment - by 2.3 times.