Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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CORRECTION OF IONOL-INDUCED HEMATOLOGIC SHIFTS IN RABBITS

Enikeyev D.A. 1 Khisamov E.N. 1 Enikeyeva S.A. 1 Idrisova L.T. 1 Mochalov K.S. 1
1 Bashkirian State Medical University of Russian Health Ministry 3
We have studied effects of ionol (butanol) at a variety of doses on the rabbit blood system. With ionol at doses of 60, 100 mg/kg, there was no evidence of changes in blood circulation elements. A single ionol dose of 150 mg/kg after 10 days caused a reduction in the content of erythrocytes, hemoglobin, haematocrit level, an increase in a range of erythrocyte diameters variation, reticulocytosis in peripheral blood. Proliferative reactivation of leucocytes – neutrophil leucocytosis with a shift to left, elevated enzyme activity – was simultaneously noted. With posthemorrhagic anemia, ionol at a dose of 30 mg/kg was shown to be effective for recovery processes in the erythron system. Such an effect of ionol at a relatively small dose is probably due to its antioxidant properties.