Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

Personal portfolio

MARKERS OF VASOREGULATING ENDOTHELIAL FUNCTION IN COMBINATION WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ARTERIAL HYPERTENSION

Akhmineeva A.K. 1 Sevostyanova I.V. 1 Polunina O.S. 1 Voronina L.P. 1
1 State budget educational institution of higher professional education «Astrakhan state medical academy»
The content of endothelin-1 and C-type natriuretic peptide in blood plasma has been studied in 35 patients with chronic obstructive pulmonary disease (COPD), in 35 patients with arterial hypertension (AH) and in 40 patients with associated pathology (COPD+AH). In the groups of patients with mononozology (COPD, AH) and in patients with a comorbid condition (COPD+AH) we diagnosed endothelial dysfunction, manifested by overproduction of endothelin-1 (ET-1) and C-type natriuretic peptide (CNUP). Statistically significant increase in the level of CNUP has been detected in patients with COPD+AH, compared with mononozology (AH, COPD), while the level of ET-1 in combination with COPD+AH remained comparable with levels in the groups of patients with COPD and AH. This indicates the fact that C-type natriuretic peptide is a more delicate and sensitive, although an indirect marker of endothelial dysfunction as compared with endothelin-1. This also indicates a greater deficit of nitric oxide in combination with COPD+AH compared with mononozology (AH, COPD). The common property of microvascular endothelium, typical of both mononosology (COPD, AH) and comorbid conditions (COPD+AH), was the reduction of the duration of vasodilation, that indicated the development of endothelial dysfunction.