Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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CHANGE ELASTIC PROPERTIES OF THE VASCULAR WALL AND ANTIOXIDATIVE EFFECT TORVAKARD AND SIMVAKARD IN PATIENTS WITH CORONARY HEART DISEASE

Zhilyaeva J.A. 1 Mikhin V.P. 1
1 Kursk State Medical University. Department of Internal Medicine № 2. Kursk
Relevance of the topic: There is a close relationship with the pharmacodynamics of statin and intensity of athe-rogenesis, the activity of lipid peroxidation and parametrs of the vascular wall stiffness. Aim: To determine the effect of generic drugs Torvakard and Simvakard in the complex therapy the parametrs of the vascular wall stif-fness and the level of lipid peroxidation in patients with chronic coronary heart disease with hypercholesterol-emia. Materials and methods: The study involved two groups of patients with stable angina FC II-III in combi-nation with hypercholesterolemia. In the I group – 52 people, in the II – 40. During the 12 weeks of the I group of patients, along with standard therapy received Torvakard (10 mg/day and 20 mg/day), depending on the initial level of cholesterol. Patients of the II group – Simvakard (10 mg/day and 20 mg/day). Determines the state of the vascular wall stiffness by volume sphygmograph («VaSera-1000, Fukuda») with the calculation of CAVI, ABI, index AI; ejection time (ET), power (PEP) and the ratio of PEP / ET, the level of degradation products in the blood lipoperoxides: AGP and MDA, C-RP. The results: The positive impact of generic drugs on the parametrs of the stiffness of the vascular wall, proved their anti-inflammatory and antioxidant effects.