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Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452
ISSN 2500-0780
ПИ №ФС77-57452
THE ACID-BASE BALANCE AND HEMOSTASIS DISTURBANCE AT THE PATIENTS HAVING ACUTE SEVERE CRANIOCEREBRAL INJURY
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Retrospective analysis of 31 medical histories belonging to the patients having acute severe craniocerebral injury from neurosurgery department of the Chita regional clinical hospital was performed from 2009 to 2011. Acid-base balance and water-electrolytic balance blood pH parameters, electrolytes and hemostasis were estimated. Patients having the diagnosis as acute severe craniocerebral injury present the first group consisting of 18 people. Patients having the diagnosis as acute severe craniocerebral injury and polyinjury present the second group consisting of 13 people. Against the background of progressive metabolic acidosis the main markers of disseminated intravascular coagulation (DIC) were found out in the both groups (the D-dimers concentration, thrombocytopenia, prolongation of international normalized ratio (INR) and the prothrombin time (PT). There were statistically significant inverse correlations between total carbonates (tCO2), concentration of hydrogen carbonates (НСО3-), buffer excesses (BE) and prothrombin time (PT). At the same time the direct corelation between total carbonates (tCO2) and the D-dimers dispersion was observed at the patients having acute severe craniocerebral injury. There are strong negative correlation bond between fibrinogen concentration and lactate, direct correlation bond between lactate and prothrombin time (PT) and activated partial thromboplastin time (APTT) at the patients having polyinjury. Existence of the correlation between metabolic acidosis and blood coagulation is the potential mechanism of progression of disseminated intravascular coagulation (DIC).