Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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CORRELATION OF INDICATORS IMMUNE AND CYTOKINE STATUS IN CHILDREN AND ADOLESCENTS WITH PULMONARY TUBERCULOSIS

Zaletsky N.P. 1 Vivchar I.S. 2
1 Danilo Halytsky National Medical University
2 “Lviv Research Institute of Epidemiology and Hygiene of the Ministry Health of Ukraine”
We studied the correlation of indicators of cytokine and immune status in children and adolescent patients with pulmonary tuberculosis of residents of different relative contamination, areas. Determined correlation between the following parameters: interleukins 1, 2, 10, immunoglobulins A, M , G, E circulating immune complexes, the total number of thymocytes, the reaction of the immune rosette, the reaction of blast transformation of lymphocytes with purified tuberculin, the reaction of blast transformation of lymphocytes with phytohaemagglutinin. Estimate the density of connections between all the studied parameters examined groups of patients was performed by determining the linear Pearson correlation coefficient (r). In the group of children and adolescent patients with pulmonary tuberculosis and living in a clean, relatively radiation field between measures of cytokines and immune status, there are predominantly (45) a strong correlation. In the group of children and adolescent patients with pulmonary tuberculosis and those living in areas contaminated by radiation between measures of cytokines and immune status are identified, mostly moderate and weak correlations . The presence of multiple correlations between measures of cytokines and immune status indicates the presence of common immune response.