Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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A COMPARATIVE STUDY OF CARDIOPROTECTIVE PROPERTIES OF SUCCINATE 3-OXIPIRIDINE AND ACETYLCISTEINATE 3-OXIPIRIDINE AT EXPERIMENTAL CHRONICAL HEART DEFICIENCY

Zamotaeva M.N. 1 Inchina V.I. 1 Chairkin I.N. 1 Drozdov I.A. 1 Kuzmichev N.D. 1 Kuznetsov U.V. 2
1 Mordovian N. D. Ogariov State University
2 Biochemical Physics Emmanuel N. M. Institute Russian Academy of Sciences Moscow
The succinate and acetylcisteinate 3-oxipiridine cardioprotective activity has been studied at experimental chronical heart deficiency in rats. The results obtained show that these preparations do not produce a substantial effect on the level of potassium, aspartataminotransferasa, malon dialdehyde and catalasa in blood plasma in rats having experimental chronic heart deficiency. It is revealed that the succinate 3-oxipiridine in a doze of 25mg/kg renders a positive inotropic effect and more explicitly, than the acetylcisteinate 3-oxipiridine, reduces stagnation phenomena in the small circle of blood circulation, but, however, it insufficiently well corrects morphological myocardium changes. The acetilcisteinate 3-oxipiridine in a doze 25mg/kg more effectively reduces the stagnation phenomena in the large circle of blood circulation and corrects structural changes in the myocardium in the given model of chronic heart deficiency. Therefore, taking into account the revealed complementary effects, it is purposeful to use both the preparations for the correction of chronic heart deficiency decompensation.