Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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PATHOGENETIC SIGNIFICANCE OF CYTOKINES IN CHRONIC HEART FAILURE OF ISCHEMIC ORIGIN, AND THE INFLUENCE OF CARDIOVASCULAR THERAPY ON IMMUNOLOGICAL PARAMETERS

Zatonsky S.А. 1 Kastanayan A.A. 1
1 The Rostov state medical university
The paper summarizes the literature data on the patogenetic effects of increased levels of proinflammatory cytokines on the progression of chronic heart failure (CHF) of ischemic origin. Separately analyzed information on incentives products cytokines in CHF and the effects of their effects on cardiomyocytes, heart muscle collagen and oxytocics activity of the heart as a whole. In addition, the influence of cardiovascular therapy on the levels of cytokines in patients with СHF: angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, β-adrenoblocators, statins. The anticitokine and immunomodulating therapy have recently been offered in addition to the generally accepted treatment for CHF as possible new and promising therapeutic approach in these patients. However, evidence in that direction at the present stage of cardiology. However, the development of new approaches of pharmacokinetic correction CHF using modulators activity of cytokine and neurohumoral systems continues, that can extend the range of therapeutic drugs.