Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

THE ACTIVITIES OF ANTIOXIDANT ENZYMES IN ERYTHROCYTE, LYMPHOCYTE AND BLOOD PLASMA OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS

Zborovskaya I.A. 1 Rogatkina T.F. 1 Myakishev M.V. 1 Martemyanov V.F. 1 Stazharov M.Y. 1 Bedina S.A. 1 Mozgovaya E.E. 1
1 Federal State Budgetary Institution « Research Institute of Clinical and Experimental Rheumatology» under the Russian Academy of Medical Sciences
Superoxide dismutase (SOD), glutathione peroxidase (GP), glutathione reductase (GR), catalase (CAT) activities were determined in erythrocyte lysate, lymphocyte lysate and blood plasma of 66 systemic lupus erythematosus (SLE) patients. SOD isozymes in erythrocytes and the level of malondialdehyde (MDA) in blood plasma of these patients were determined in addition. CAT, SOD, GP activities in blood plasma, SOD, GP, GR activities in erythrocyte lysate were lower; SOD, GP, GR activities in lymphocyte lysate, MDA level were higher and SOD-1 isoenzyme fraction was more in patients with the 1st degree of the pathological process activity in comparison with healthy people. The increase of the pathological process activity as well as the acute course of the SLE was accompanied by the increase of GP, GR activities in blood plasma, SOD, GP, GR activities in erythrocyte lysate, MDA level and the decrease of SOD, GP, GR activities in lymphocyte lysate. The essential enzyme differences were revealed between all activity degrees and variants of the disease. The definition of SOD, GP, GR, CAT activities helps to diagnose the degree of the pathological process activity, character of the course and also helps monitor the effectiveness of SLE therapy.