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Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452
ISSN 2500-0780
ПИ №ФС77-57452
COMPARISON OF SOME DRUG-INDUCED EFFECTS OF ETOKSIDOL IN DIFFERENT ANALOG STUDIES OF METOBOLIC DISORDERS
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During the analog study of alloxan hyperglycemia, the use of etoksidol increases the resulting indices of heart rate variability. It prevents activation of the sympathetic components of heart rate regulation and activates its parasympathetic components. It also does not affect the duration and estimates of the QT interval. In analog study of dyslipidemia including a food-diet with high amount of cholesterol and cancellation of lovastatin, the use of etoksidol prevents the imbalance of autonomic regulation and increases the estimates of the QTd and QTdc. During the anolog study of combined metabolic disorders and cancellation of lovastatin, the use of etoksidol increases the resulting indices of heart rate variability, it also increases the activity of the parasympathetic regulation, it normalizes the autonomic balance and reduces the estimates of QT interval. In all this cases of metabolic disorders the use of 3-hydroxypyridine malate (etoksidol) limites the growth of myocardial electrical instability. The most pronounced effect was founded during the analog study of combined metabolic disorders.