Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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INDICATORS OF ANTIOXIDATIVE DEFENSE FERMENTS ACTIVITY AND THEIR DYNAMICS IN CASE OF PATIENTS WITH OSTEOARTHROSIS IN THE PROCESS OF TREATMENT WITH DRUGS IMPROVING MICROCIRCULATION AND UNDER SYSTEMIC ENZYME THERAPY

Ibragimova L.A. 1 Myrsaeva G.H. 1 Andrianova O.L. 1 Makeeva G.K. 1 Amineva L.H. 1
1 SBGI HPE «Bashkirian State Medical University» Health Ministry of the Russian Federation
The course of osteoarthrosis (ОА) is characterized by degenerative changes in joints cartilage and periarticular tissues, microcirculation disorders, hypoxia. The aim of the study was to study the dynamic AOP enzymes catalase and superoxide dismutase, the determination of levels of cytokines IL-1β, IL-4, TNF-α in plasma in patients with OA, and their relationship with the severity and assessment of the effectiveness of integrated treatment with the antioxidant and systemic enzyme therapy. In 110 patients with a diagnosis of the comprehensive survey was conducted before and after treatment. Determined by the severity of articular syndrome with the scale of scoring depending on laboratory parameters. Surveyed patients with moderate to severe disease were divided into two comparable groups: the main group and the comparison group. We have analyzed the effectiveness of the treatment in patients with moderate to severe disease severity. The main group of patients (35 men) took a comprehensive treatment scheme in combination with systemic enzyme therapy (Wobenzym). The results showed that in the process of studying the antioxidant enzyme system (AOS), catalase and superoxide dismutase (SOD) traced the relationship between the content of lipid peroxidation (LPO) levels of cytokines IL-1β, IL-4, TNF-α in the blood plasma patients with OA. The relationship between the processes of lipid peroxidation, enzyme activity and the severity of the HPA, and evaluate the effectiveness of integrated treatment with systemic enzyme therapy.