Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ANTI-INFLAMMATORY EFFECT OF ASCORBATE CHITOSAN IN THE PERIODONTAL DISEASE TREATMENT

Ivanov P.V. 1 Zudina I.V. 2 Bulkina N.V. 3 Vedyaeva A.P. 3 Ivanova E.V. 2
1 Penza State University
2 Saratov State University n.a. N.G. Chernyshevsky
3 Saratov State Medical University n.a. V.I. Razumovsky
The article stadies the effect of the gum treatment with the gel-like form of the ascorbate chitosan on the dynamics of the changes in the level of cytokines (TNF-α, IL-1β, IL-8 and IL-1ra) in the periodontal pockets liquid from patients who have the generalized type of the inflammation in the periodontal tissues. It was found that chitosan ascorbate exhibits a pronounced anti-inflammatory activity, probably, due to the regulation of the IL-1β and TNF-α cytokine levels in the inflammatory focus. We have identified in this paper patterns suggest that the therapeutic effect of the gel 8% ascorbate HTZ not only due to prolonged readjustment of teeth-gums due to a pronounced antibacterial activity HTZ, but its effect on the immuno-effectors of innate immunity. The mechanism of action of polycationic heteropolysaccharide on living cells, apparently the same as that of the polycationic antimicrobial proteins (primarily defensins β).