Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ANTI-INFLAMMATORY EFFECT OF ASCORBATE CHITOSAN IN THE PERIODONTAL DISEASE TREATMENT

Ivanov P.V. 1 Zudina I.V. 2 Bulkina N.V. 3 Vedyaeva A.P. 3 Ivanova E.V. 2
1 Penza State University
2 Saratov State University n.a. N.G. Chernyshevsky
3 Saratov State Medical University n.a. V.I. Razumovsky
The article stadies the effect of the gum treatment with the gel-like form of the ascorbate chitosan on the dynamics of the changes in the level of cytokines (TNF-α, IL-1β, IL-8 and IL-1ra) in the periodontal pockets liquid from patients who have the generalized type of the inflammation in the periodontal tissues. It was found that chitosan ascorbate exhibits a pronounced anti-inflammatory activity, probably, due to the regulation of the IL-1β and TNF-α cytokine levels in the inflammatory focus. We have identified in this paper patterns suggest that the therapeutic effect of the gel 8% ascorbate HTZ not only due to prolonged readjustment of teeth-gums due to a pronounced antibacterial activity HTZ, but its effect on the immuno-effectors of innate immunity. The mechanism of action of polycationic heteropolysaccharide on living cells, apparently the same as that of the polycationic antimicrobial proteins (primarily defensins β).

Библиографическая ссылка

Иванов П.В., Зудина И.В., Булкина Н.В., Ведяева А.П., Иванова Е.В. ПРОТИВОВОСПАЛИТЕЛЬНЫЙ ЭФФЕКТ АСКОРБАТА ХИТОЗАНА В КОМПЛЕКСНОЙ ТЕРАПИИ ЗАБОЛЕВАНИЙ ПАРОДОНТА // Научное обозрение. Медицинские науки. 2014. № 1. С. 130-131;
URL: https://science-medicine.ru/en/article/view?id=188 (дата обращения: 25.05.2026).