Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE OZONIZED MEDIAS EFFECTS ON THE FERMENTATIVE ACTIVITY OF THE BLOOD LYMPHOCYTES UNDER CHEMOTHERAPY OF THE MAMMARY GLAND CANCER

Kit O.I. 1 Kasyanenko V.N. 1 Shatova Y.S. 1 Shikhliarova A.I. 1 Maryanovskaya G.Y. 1 Barsukova L.P. 1 Korobeinikova E.P. 1 Rezinkova I.A. 1
1 FGBU Rostov Cancer Research Institute
The effects of the blood ozonization, combined with the polychemotherapy, on the energy state of the peripheral blood lymphocytes in women with locally invasive mammary gland cancer, have been researched. For this purpose, the activity of the succinate dehydrogenase and ά-glycerophosphate dehydrogenase, being the key ferments of the main energy-providing Krebs cycle, was tested, by using the quantitative cytochemical technique. The complex exposure was held by 2 identical courses with a two-week break between them. The first ozonization led, anyway, to a decrease of level of the metabolic acidosis, whose hundred-per-cent removal occured by the end of the treatment. There was shown a trustworthy increase of the blood lymphocytes pool with a high content of the succinate dehydrogenase by the end of each course of the treatment. Thus the blood ozonization contributes to overcoming the hypoxic state, to stimulating the oxygen-dependent ways of the organism functioning, and to removing the metabolic acidosis.