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Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452
ISSN 2500-0780
ПИ №ФС77-57452
EFFICACY OF BRIEF ACUTE TREATMENT IN PATIENTS WITH PARANOID EARLY-ONSET SCHIZOPHRENIA DEPENDING BDNF GENE POLYMORPHISM
Kolesnichenko E.V. 1
Barylnik Y.B. 1
Golimbet V.E. 2
1 Saratov State Medical University named V.I.Razumovsky
2 Mental Health Research Center Russian Academy of Medical Sciences
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We investigated the efficacy of different variants of six-week antipsychotic treatment in patients with paranoid schizophrenia with early onset depending on the polymorphism Val66Met brain-derived neurotrophic factor gene (BDNF gene). We examined 142 patients with paranoid schizophrenia with early onset who were admitted to psychiatric hospitals of Saratov and Saratov region (Russia) for the exacerbation of psychosis. The efficacy of antipsychotic treatment was lower in patients with the presence of Met allele of Val66Met polymorphism of the BDNF gene. It is concluded that the relationship of the Val66Met polymorphism of the BDNF gene with the efficiency of short-term antipsychotic treatment of patients with paranoid schizophrenia with early onset. It is suggested that Met allele of Val66Met polymorphism of the BDNF gene determines the formation of resistance to antipsychotic treatment in accordance with the criteria of Kane in patients with paranoid schizophrenia with early onset.