Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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MAST THYMUS CELLS ON THE BACKGROUND OF COLON ADENOCARCINOMA

Kostrova O.Yu. 1 Merkulova L.M. 1 Struchko G.Yu. 1 Mikhaylova M.N. 1 Moskvichev E.V. 1
1 FGBOUVPO “Chuvash State University
Using immunohistochemistry, luminescent-histochemical and general histologic methods the thymus of nonlinear laboratory male rats at 1, 2, 3 and 4 months after the introduction of a carcinogen was studied. Found that on the background of colon adenocarcinoma observed significant morphological changes of mast cells of the thymus. The changes were more pronounced in the last term of study - 4 months after the end of injection. There were revealed that at mast cells reduced serotonin, catecholamines and histamine on this term study. The ratio (serotonin + histamine) / catecholamines increases indicate the suppression of the functional activity of mast cells of the thymus in this period of the study. The administration of 1,2-dimethylhydrazine increases the number of mast cells, mainly due to degranulated forms. By immunohistochemistry revealed an increase in the number of tryptase positive mast cells.