Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

Personal portfolio

TRANSFORMING GROWTH FACTOR IN A CASE OF ABDOMINAL HERNIA

Bart I.I. 1, 2 Ivanov V.P. 1 Ivanov S.V. 1 Trubnikova E.V. 3
1 Kursk state medical university
2 Science laboratory of ecological medicine of kursk state medical university
3 Kursk state university
We presents a polymorphism of a transforming growth factor at patients with abdominal hernias in article. Violation of qualitative structure of a connecting tissue is one of the main mechanisms of abdominal hernias. The transforming growth factor is cytokine, modulating cellular growth, an inflammation, proliferation and a differentiation of extracellular matrix and mechanisms of deposition and apoptosis. 8 of its polymorphisms are known. We researched an analysis of -509 C/T of this gene in our study. Research was conducted on 289 patients. 143 persons with abdominal hernias and 146 people of control group. Distinctions of gender and age structure between groups were absent. The molecular and genetic analysis was made by PCR-RFLP. As a result we found a statistically reliable distinctions in frequencies of both alleles of this polymorphism between groups. Distinctions of the frequency of wild and mutant genotypes with considerable shift towards mutant genotypes in a group of patients with abdominal hernias in comparison with persons of control group were also founded.