Kuznetsov P.L. 1
Borzunov V.M. 1
Bessonova E.N. 2
Udilov V.S. 1
Verevshchikov V.K. 1
1 SBEI HPE «Ural State Medical Academy
2 SHCI «Sverdlovsk regional hospital № 1»
In the course of chronic HBV infection is progressing process of fibrogenesis the liver. In the study of liver biopsy samples 54 patients with chronic viral hepatitis B identified a wide range of morphological changes: infiltration tissue lymphocytes, the expansion of the portal tracts due to fibrosis and moderate lymphocytic infiltration, the formation of porto-portal septum, stepped necrosis, bottled infiltration of hepatocytes, the detection of “dull glassy” hepatocytes and “sand cores”. The progression of HBV-infection increases the frequency of detection of diffuse lymphocytic infiltration, the number of porto-portal septum and stepped necrosis. After the combined antiviral therapy is registered improvement of morphological structure of the liver. Indicators of the syndrome of endogenous intoxication have a direct correlation with the process of fibrogenesis in HBV infection. After 2-3 years in patients with HBV-infection without etiotropic treatment significantly increased toxicity index and decreased reserve albumin binding in comparison with patients treated with therapy.
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