Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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MARKERS OF APOPTOSIS OF IMMUNOCOMPETENT CELLS AT DIABETES OF THE 1 ST TYPE BY CHILDREN

Barycheva L.Y. 1 Erdni-Goryaeva N.E. 1
1 GBOU VPO “Stavropol state medical university” Health Ministry of Russian Federation
25 children aged 3–15 years are examined. The aim of the research was to determine the readiness to apoptosis of lymphocytes and neutrophils of peripheral blood with help of the definition of apoptosis markers – CD95, CD95L, BSL2. When assessing the apoptosis of immunocompetent cells is fixed a decrease of readiness to programmed cell death of lymphocytes and increase of neutrophils. The most expressed changes are registered in the group aged 7–15 years with the disease experience more than 3 years. The data may be the indication of the programmed death suppressing of autoreactive lymphocytes in pancreatic tissue, that promotes the prolongation of the immune response. Increasing of the share of leukocyte cells expressing CD95L can promote to strengthening of processes of programmed cell death in islet β-cells of the pancreas, indurated immunocompetent cells.