Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

MARKERS OF FAILURE OF ADAPTATION IN THE SHARP PERIOD OF THE TRAUMATIC ILLNESS

Lebedeva Е.А. 1
1 Rostov state medical university
The purpose research - identification of markers of failure of adaptation in the sharp period of a traumatic illness at a serious сoncomitant brain injury is conducted observation longitudinal kogortny research of 66 patients. Studying of nonspecific protective and adaptive reactions at a serious сoncomitant brain injury allowed to establish markers of failure of adaptation in the first six days and after six days after a trauma. For the 2nd days after a trauma it is obviously possible to carry out the forecast of possible failure of adaptation within the first week. In later terms really to carry out forecasting of possible failure of adaptation for the 7th days after a trauma. Increase of level pro-inflammatory cytokines in blood, increase in level of products of peroxidation of lipids in blood plasma against early decrease in the shiffovy bases in erythrocytes and the speed of free radical processes in an organism for the 2nd days led to failure of adaptive opportunities of an organism during the first 6 days after a trauma. In adaptation failure from 7 to 28 days after a trauma are involved high production pro-inflammatory cytokines, the uneven speed of free radical processes against rough conformational violations of structure of proteins of membranes of the cages, being characterized increase in level inside - and intermolecular stitchings.