Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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CLINICAL EFFICIENCY OF TARGET INTENSIVE TREATMENT OF THE сONCOMITANT BRAIN INJURY WITH EPOETIN ALFA, CYTOFLAVIN, HYPERBARIC OXYGENATION

Lebedeva Е.А. 1 Markaryan E.G. 2 Kaminsky M.Yu. 1 Belyaevsky S.A. 2
1 Rostov state medical university
2 City hospital first help
Research objective: determination of clinical efficiency of treatment of the сoncomitant brain injury (TBI) by target application epoetin alfa (EPO-α), cytoflavin and hyperbaric oxygenation (GBO) under low excessive pressure in a pressure chamber. Prospektivny controlled blind randomized research of 210 patients is conducted. Treatment EPO-α (36 people) was carried out, since 1 days of the post-traumatic period, in a course dose not less than 50000 ME. Cytoflavin started entering (43 people) since 2 days of the post-traumatic period on 10 ml of a preparation within 7 days. Course GBO (32 persons) began with 7-10 days and consisted of 7 daily sessions in a mode (1,2 1,5 ATA). The control group consisted of 99 people and received a standard complex of intensive treatment. Groups of comparison were comparable on a sex, age, weight of damage and a condition at the time of receipt in a hospital. At application of complex intensive treatment with target inclusion of EPO-α, cytoflavin and GBO was registered decrease in cases of development of a multiple organ dysfunction (with an involvement of three and more bodies) into 1,3 times (р=0,012); reduction of terms of knocking over of a organ dysfunction by 1,3 times days (р=0,019); increase in number of the survived patients by 1,4 times (р<0,001); growth number of patients with good restoration of the social status allowing them to come back to a former stereotype of life by 1,9 times (р=0,037).