Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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FEATURES OF THE INNATE AND ADAPTIVE IMMUNITY IN INFANTS WITH GENERALIZED CYTOMEGALOVIRUS INFECTION

Levkovich A.Y. 1 Afonin A.A. 1
1 FGSFO “Rostov Research Institute of Obstetrics and Pediatrics” of the Ministry of Health of the Russia
Сlinical and laboratory examination of 47 infants with generalized cytomegalovirus infection (CMV) in the early neonatal period is conducted (main group). In 29 children (I subgroup) had generalized CMV infection with complete clinical symptomatology, in 18 children (II subgroup) - CMV infection with incomplete clinical symptoms. The control group consisted of 26 were clinically healthy newborns. The expression of TLR-2, TLR-6 in peripheral blood monocytes, frequency polymorphism Ser249Pro gene TLR-6, interrelation of pro-and anti-inflammatory cytokines and chemokines (IFN-γ, IFN-α, IL-8, IL-4, MCP-1) at newborns with various forms of generalized CMV infection are studied. It is revealed that an imbalance of factors innate and adaptive immune response leads to a change in the interaction responsible for the enhancement of viral replication, shift differentiation of T-helper cells toward Th2, not ensuring the formation of an effective antiviral immune response, which is one of the mechanisms of generalized CMV infection.