Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

GSK3B GENE POLYMORPHISM IN DEPRESSIVE DISORDERS

Losenkov I.S. 1 Vyalova N.M. 1 Simutkin G.G. 1 Ivanova S.A. 1, 2 Bokhan N.A. 1
1 Mental Health Research Institute SB RAMSci
2 National Research Tomsk Polytechnic University
Glycogensyntase kinase-3β (GSK-3β) is a multifunctional intracellular regulatory protein which plays a key role in various neuronal cell processes like synaptic plasticity, forming neuronal polarity, synaptic transduction, neurodegeneration, growth and death of neurons. The aim of this study was to find association of GSK3B gene polymorphisms with depressive disorders. 152 DNA samples taken from depressive patients and 154 DNA samples taken from physically and mentally healthy donors were genotyped. Two single nucleotide polymorphisms (SNP) rs334558 and rs645582 of GSK3B gene were genotyped. Investigation showed no association of these polymorphisms with depressive disorders pathology. Further investigations of GSK-3β role in this pathology are needed.