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Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452
ISSN 2500-0780
ПИ №ФС77-57452
INFLUENCE OF DRUGS LIPOIC ACID ON PROOXIDANT-ANTIOXIDANT INDICATORS OF BLOOD IN DIABETES MELLITUS AND HYPOTHYROIDISM
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During the studies found that patients with endocrine disorders (diabetes mellitus (DM) type 1 and 2, hypothyroidism) observed the development of imbalances in the prooxidant-antioxidant system, accompanied by strengthening of free radical oxidation (FRO) and a decrease in the capacity of the antioxidant system (AOS) blood. Against the background of ongoing conventional therapy on the 10th knocks treatment could not achieve full recovery of the prooxidant-antioxidant balance, in connection with which the management of patients were used drugs lipoic acid has an antioxidant effect. In terms of additional introduction to the treatment regimen of patients with endocrine disorders funds antioxidant correction indicators FRO on the 10th day of treatment decreased to a greater extent (by 26.4-31.4%, p<0.05), than in patients with conventional treatment. In addition, there was a significant increase in performance AOS (on 27.6-44.1%, p<0.05) levels in patients receiving complex treatment including drugs lipoic acid, thus improving the effectiveness of the therapy in DM type 1 and 2 type and hypothyroidism. Such an approach can lead to a reduction in the number of complications in patients with these nosologies.