Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE ANTI-ARRYTHMIC ACTIVITY QUARTER DERIVATIVES ANTI-ARRYTHMIC PREPARATIONS

Makarova Y.A. 1, Belova L.A. 1, Balashov V.P. 1, Slesarev V.O. 1, Mokeikina O.V. 1
1 Federal State Budgetary Educational Institution of Higher Professional Education»Mordovian state university named after N.P. Оgaryov»
The anti-arrhythmic activity of the atenolol quarter derivatives LХТ-2-05 and LХТ-К539 has been studied in equitoxical dozes of 1 % of LD50 specified for mice at intra-abdominal injections. The activity being estimated by 3 models: ventricle arrhythmia at later stages of experimental myocardial infarct in dogs, aconitin and calcicum chloride arrhythmia in mice. The preparations used are shown to possess anti-arrhythmic properties, and by a number of indices exceed their structural predecessors. Quarter derivatives of nitrogen atoms in the atenolol molecule afford to obtain preparations (LХТ-2-05 and LХТ-К539), effective for the models whose genesis is mediated by calcium homeostasis disorder and by the disorder of the sodium channel functions.

Библиографическая ссылка

Макарова Ю.А., Белова Л.А., Балашов В.П., Слесарев В.О., Мокейкина О.В. ПРОТИВОАРИТМИЧЕСКАЯ АКТИВНОСТЬ ЧЕТВЕРТИЧНЫХ ПРОИЗВОДНЫХ АНТИАРИТМИЧЕСКИХ СРЕДСТВ // Научное обозрение. Медицинские науки. 2014. № 2. С. 51-51;
URL: https://science-medicine.ru/en/article/view?id=282 (дата обращения: 07.06.2026).