Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE ANTI-ARRYTHMIC ACTIVITY QUARTER DERIVATIVES ANTI-ARRYTHMIC PREPARATIONS

Makarova Y.A. 1 Belova L.A. 1 Balashov V.P. 1 Slesarev V.O. 1 Mokeikina O.V. 1
1 Federal State Budgetary Educational Institution of Higher Professional Education»Mordovian state university named after N.P. Оgaryov»
The anti-arrhythmic activity of the atenolol quarter derivatives LХТ-2-05 and LХТ-К539 has been studied in equitoxical dozes of 1 % of LD50 specified for mice at intra-abdominal injections. The activity being estimated by 3 models: ventricle arrhythmia at later stages of experimental myocardial infarct in dogs, aconitin and calcicum chloride arrhythmia in mice. The preparations used are shown to possess anti-arrhythmic properties, and by a number of indices exceed their structural predecessors. Quarter derivatives of nitrogen atoms in the atenolol molecule afford to obtain preparations (LХТ-2-05 and LХТ-К539), effective for the models whose genesis is mediated by calcium homeostasis disorder and by the disorder of the sodium channel functions.