Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ASSESSMENT OF FACTORSINNATE IMMUNITY IN DIFFERENT PHASES OF A CURRENTOF CROHN’S DISEASE

Mamedova L.N. 1
1 Rostov Medical State University
The role pattern recognition receptors in the pathogenetic mechanisms of Crohn’s disease. A dynamic assessment expression of TLR 2,4,6 on blood monocytes in CD in different phases of its course. Take into account changes in the expression of TLR 2,4,6 relapseand remission of CD, with varying degrees of severity, assessed according to an index Best, different lengths of the inflammatory process and the long history of the disease, assessed the microbial landscape of the intestine. The data on the reliable increase in the number of monocytes expressing TLR 2,4,6, in the period of recurrence CD, changing their number depending on the severity and duration of the disease, as well as in violation of the intestinal microflora. There was a significant relationship between the level of monocytes expressing on their surface TLR 2,4,6 and clinical markers of recurrence of CD.