Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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INTERCELLULAR MATRIX CONDITION AT PATIENTS WITH GLAUCOMA

Markelova E.V. 1 Kirienko A.V. 1
1 GBOU VPO the Pacific state medical university Ministries of health and social development Russia Federation
Patients with primary open-angle glaucoma (POAG) I-III stages (133 persons) and closed-angle glaucoma (CAG) the I-III stages (27 people) were surveyed. Definition of the maintenance of a metalproteinase-9, its fabric inhibitor I of type and kompleksovmmr-9/TIMP-I and MMP-9/TIMP-II in plaintive liquid at patients with POAG and CAG of different stages is carried out metodtverdofazny IFA with application of specific reactants «R&D Diagnostics Inc.» (USA). For determination of reliability of distinctions it was used nonparametric statistics (a median, the bottom and top quartile, Mann-Whitney Vilkonson’s criterion, χ2), with SPSS v 16 program use.At glaucoma patients violations in system of a metalproteinase-9 and its fabric inhibitors I and II type, being characterized by local hyperproduction of MMR-9 and its complexes with TIMP-I and TIMP-II irrespective of glaucoma type are revealed, at a lack of free fabric inhibitor I of type at patients with POUG. Extent of violations in system of a metalproteinase-9 and its fabric inhibitors is interfaced to weight of a disease both at POUG, and at PZUG that testifies to an essential role of violations intercellular matrix in pathogenesisglaucomas. MMR-9 increase in plaintive liquid can be considered more than 80,0 pg/ml as additional criterion of early diagnostics of POAG.