Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

ANTIOXIDANTS IN THE TREATMENT OF EXPERIMENTAL PERITONITIS CAUSED BY ESCHERICHIA COLI

Miroshnichenko A.G. 1 Bryukhanov V.M. 1 Butakova L.Y. 1 Gossen I.E. 1 Perfilyev V.Y. 1 Smirnov P.V. 1
1 Altai State Medical University
Was conducted a comparative study of the effect of antioxidants (ascorbic acid, methylethylpiridinol , N-acetylcysteine) on the effectiveness of antibacterial agents (gentamicin, ciprofloxacin, ceftazidime, chloramphenicol, tetracycline) in experimental peritonitis caused by Escherichia coli. Experiments were performed on Wistar rats weighing 240-275 g. Doses were set in accordance with interspecific transfer rules based therapeutic doses used in humans. It was established that the effectiveness of antioxidants in peritonitis caused by Escherichia coli is dependent on the chemotherapeutic agents. Antioxidants prevent the implementation of the antibacterial action of gentamicin, it does not reduce the nephrotoxic effects of the antibiotic. All studied antioxidants reduce prooxidant effect of chloramphenicol and ciprofloxacin, without affecting their antibacterial activity. Combined use of antioxidants and tetracycline inappropriate.