Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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PHARMACOLOGICAL AND MICROBIOLOGICAL ASPECTS OF THE EFFECTS OF METHYLETHYLPYRIDINOL ON CEFTAZIDIME ACTIVITY IN VITRO

Miroshnichenko A.G. 1 Bryukhanov V.M. 1 Butakova L.Y. 1 Gossen I.E. 1 Perfilyev V.Y. 1 Smirnov P.V. 1
1 Altai State Medical University
Studied the effect of methylethylpyridinol at concentrations of 0.5, 1, 2, and 4 mM on the sensitivity of Escherichia coli strains to ceftazidime. Incubation and dynamic monitoring of the development of strains were carried out for 24 hours. Found that methylethylpyridinol is directly proportional to its concentration potentiates the effects of ceftazidime against Escherichia coli. From an efficiency standpoint pharmacotherapy prerequisite is that influence adherence antibiotic dosing regimen in order to maintain constant its concentration. To assess the effect of compounds modulating the activity of antibiotics unstable in solutions, the traditional approach to the assessment of bacterial cultures after 24 hours is incorrect. Relevant research should be dynamic nature of the assessment characteristics of the development of microorganisms in the individual phases. The data must be considered when using ceftazidime infection Escherichia coli.