Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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СOMPARATIVE STUDY OF MYELOPROTECTIVE EFFICIENCY OF DICARBAMIN IN DIFFERENT DOSES AND DOSING REGIMENS IN CONDITIONS OF EXPERIMENTAL POST-RADIATION BONE-MARROW SYNDROME

Moiseeva I.Y. 1 Nikishin S.A. 1 Vodopjanova O.A. 1 Ionova S.A. 1 Nebolsin V.E. 2
1 Penza State Iniversity
2 “Pharmenterprise Inc.”
The influenceof Dicarbaminonmyelopoiesisin a health-care dosing regimen in a dose of 4mg per kg and in a therapeutic regimen in doses of 4 mg per kg and 15 mg per kg in conditions of experimentalpost-radiationbone marrowsyndromeofrabbits has been investigated.The intake of bone marrowfor researchwas carried out by puncture of the animals ilium before the experiment andat 3, 7, 10, 14, 21, 28 experiment days. Dicarbamin provided a high level of protection of proliferatinghematopoieticprecursors inthe early period afterradiation exposure, which was expressed in a statistically significant decrease of intensity and duration of post-radiationdeficiencyof bone-marrow tissue hematopoietic cells. Dicarbamin promoted the normalization of proliferation and differentiation processes in myelocarocytes subpopulations; the protectiveeffect of thedrug embraced all hematopoietic stem cells.