Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ABOUT MYELOPROTECTIVE EFFECT OF LEUCOSTIM IN CONDITIONS OF EXPERIMENTAL RADIATION DAMAGES OF HEMATOPOIETIC BONE MARROW

Moiseeva I.Y. 1 Ionicheva L.V. 1 Rodina O.P. 1 Nikishin S.A. 1 Ionova S.A. 1 Kiseleva D.D. 1
1 Penza State University
The in fluenceonmyelopoiesis of filgrastim (Leukostim, «Biocad» Inc., Russia) in a dose of 16mg per kgwith a singlesubcutaneous injectionat 1 h afterirradiation in experimentalpost-radiationbone marrowsyndromeofrabbits has been investigated.The intake of bone marrowfor researchwas carried out by puncture of the animals ilium before the experiment andat 3, 7, 10, 14, 21, 28 experiment days.It is shown thatLeukostim provided a high level of protection of proliferatinghematopoieticprecursors inthe early period afterradiation exposure, which was reflected in the preventionof post-radiationdeficiencyof cells composing neutrophil, monocyte, lymphocytebloodshoots; the protectiveproperties of investigateddrug in relation to erythrocariocyticandmegakaryocyticlines were not expressedsubstantially.