Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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CLINICAL STUDY OF APPLICATION COMBINED DRUGS IN COMPLEX TREATMENT OF TUBERCULOSIS

Morozova T.I. 1, 2 Doktorova N.P. 1, 2 Barinboym O.N. 1, 2 Parolina L.E. 2
1 Regional clinical TB Dispensary
2 Saratov State Medical University n.a. V.I. Razumovsky
The authors analyzed the clinical efficiency of treatment patients with high risk of development of drug resistant M.Tuberculosis with application the combined drug «Kombitub-neo» with the fixed dosages. The first group was consisted from patients, which received combined preparation of «Kombitub-neo», n=21. The second group included patients, who were treated by complex of separate drugs, n=27. During supervision over 48 patients with active pulmonary tuberculosis the equivalent clinical efficiency of usage of various forms of medicines in the intensive phase of treatment was established. In the first group the duration of chemotherapy: median 175 of doses (interquartile range from 174 to 185 doses). In the second group the median was 165 doses (interquartile range from 155 to 185 doses). The authors established the optimum terms (more than 120 days) of intensive stationary stage of treatment. They found that the results of treatment do not depend of chosen forms of anti-tuberculosis drugs.