Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

Personal portfolio

COMPARATIVE CHARACTERISTICS OF THYMIC ATROPHY IN EXPERIMENTAL CARCINOGENESIS AND AGE-RELATED INVOLUTION (MORPHOLOGIC AND IMMUNOHISTOCHEMICAL STUDY)

Moskvichev E.V. 1
1 Chuvash State University named after I.N. Ulyanov». The Medicine faculty
The morphology of thymus of the rats with experimental tumors of the colon was studied with use of immunohistochemistry. We made comparative investigation of the changes in age-related involution. It was found, that number of mature medullar thymocytes remains at a constant level during the experiment, in contrast to age-atrophy of thymus, where their number is gradually reduced. The formation of malignant tumor in the later stages of the experiment is accompanied by an increase in the number of cells of neuroendocrine and neuroectodermal origin in structures of thymocyte microenvironment. In the thymic cortex noted an increase expression of cell proliferation marker Ki-67 at the background of increased numbers of CD3+ thymocytes. Probably, these changes may be due to both increased differentiation of cortical thymocytes, and the toxic effects of the tumor on the bone marrow and decreased supply of immature CD3- precursor cells in the thymus. The results of the study indicate the possibility of tumorogenesis to change some features of thymopoesis. They also supplement the information about current age-relaterd atrophy of the thymus.