Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ROLE OF THE HYPOTHALAMIC- PITUITARY-ADRENAL AXIS IN GENESIS MENSTRUAL DISORDERS IN GIRLS WITH PUBERTAL HYPERANDROGENISM

Moskovkina A.V. 1 Linde V.A. 1 Puzikova O.Z. 1
1 Rostov Scientific and Research Institute of Obstetrics and Pediatrics
An assessment of the role of the hypothalamic -pituitary- adrenal axis in the pathogenesis of menstrual cycle in pubertal girls with hyperandrogenism. Revealed significant differences between the basal levels of CRH and ACTH in patients with HA compared with the control group. This fact is explained by the fact that extreme emotional lability, the impact of various external and internal factors in adolescents can dramatically increase the activity of the hypothalamic -pituitary -adrenal system. The trigger point is the stimulation of the hypothalamus by various kinds of stress , making provocative violation of CRH increased ACTH release , and as a result, activation of the adrenal hormones. More pronounced changes in the secretion of these peptide regulators in the group with oligomenorrhea , as well as their correlation with increased secretion of adrenal androgens confirms the pathogenetic involvement of the hypothalamic -pituitary -adrenal axis in the formation of ovarian dysfunction in hyperandrogenic adolescent girls. Possible mechanisms of declining ovarian function in the syndrome of hyperandrogenism , so are the excessive neurohormonal activation of the hypothalamic -pituitary- adrenal axis , increasing the release of adrenal androgens and due to this arrhythmia secretion of gonadotropins.