Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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COMPARATIVE ANALYSIS OF CHANGES IN EXERCISE TOLERANCE IN PATIENTS WITH CORONARY HEART DISEASE UNDER THE INFLUENCE OF THERAPY BASED ON BISOPROLOL AND IVABRADINE

Nedoruba E.A. 1 Bagmet A.D. 1 Tautina T.V. 1
1 The Rostov State Medical University
To conduct the study were selected 64 patients with ischemic heart disease (stable angina I-III functional class), patient age from 45 to 74 years. The diagnosis of angina I-III FC verified according to the treadmill test, as recommended by the Canadian Association of pits, cardiologists, clinical and anamnestic characteristics. A prerequisite to enroll patients in the study was the presence of sustained sinus rhythm and the absence of significant mitral valve regurgitation on the results of echocardiography. After defining the basic parameters examined patients were randomized into 2 groups. Patients first group (32 persons), in addition to standard therapy (aspirin, statins, ACE inhibitors, nitrates) for 12 weeks received a beta-blocker bisoprolol 5-10 mg / day. Patients second group (32 subjects), in addition to standard therapy for 12 weeks received If-inhibitor ivabradine at a dose of 5-7.5 mg 2 times a day. Terminating an ECG test was performed on a treadmill «Stress-Test ST-2001» (Netherlands) with the use of a modified Bruce protocol.УДК 618.11-006.6:616-08.