Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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THE POSSIBILITY OF REDUCING THE TUMOR TOXICITY IN PATIENTS WITH OVARIAN CANCER STAGE III – IV

Nerodo G.A. 1 Ushakova N.D. 1 Mkrtchyan E.T. 1 Menshenina A.P. 1
1 Federal State Budget Institution «Rostov Research Oncologic Institute» Ministry of Health of Russia 63
We investigated the role and place of plasmapheresis in the complex of accompanying therapy of ovarian cancer patients to provide them with planned cancer treatment. 24 patients with ascites of ovarian cancer stage III-IV aged from 44 to 74 years with the presence of endotoxemia after clinical and laboratory examinations were performed plasmapheresis. Blood parameters, such as leukocyte intoxication index, serum creatinine and urea, C-reactive protein were evaluated before and after the gravitational plasmapheresis. Analysis of the results allowed us to establish that the conduct of a session of plasmapheresis leads to lower levels of creatinine and blood urea, reduced levels of C-reactive protein, leukocyte index of intoxication and reactive response of neutrophils. The normalization of these indicators has allowed for all patients included in the study, to conduct adequate courses of neoadjuvant chemotherapy in time in order to transfer patients to resectable state. The summarized results of the presented data demonstrate the usefulness of including plasmapheresis in the complex treatment of ovarian cancer patients with endotoxemia in order to conduct a timely and complete chemotherapy.