Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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ERYTHROPOIETIN AS A REGULATOR OF THE PLATELET GLYCOPROTEIN EXPRESSION

Osikov M.V. 1 Grigoryev T.A. 2 Fedosov A.A. 1 Kozochkin D.A. 1 Ilinykh M.A. 1
1 Chelyabinsk State Medical Academyof Health Ministry of Russia
2 Chelyabinsk Regional Hospital
Pleiotropic effects of erythropoietin (EPO) may be related to its effect on the expression of platelet glycoproteins. To test this hypothesis the quantitative and qualitative analysis of glycoproteins on platelets in cases of endogenous erythropoietin (EPO) deficiency and the administration of exogenous EPO in 62 patients with chronic renal failure (CRF) on dialysis in Chelyabinsk Regional Hospital was conducted. In patients with chronic renal failure the expression of glycoproteins Gp IIb-IIIa is increased by 35%, Gp IIb - by 43%, Gp Ib - 52% in comparison with the group of healthy volunteers. The number of cells expressing the Gp Ib was not significantly changed, proving the receptor density enhancement. After hemodialysis Gp IIb-IIIa and Gp Ib expression returned to normal levels. The administration of exogenous EPO in patients with CRF in a total dose of about 40,000 IU reduces the number of Ib receptor and IIb-IIIa complex, and the latter up to the level of healthy people, and it is likely due to subunit IIIa, because IIb subunit expression was not significantly changed. Thus, EPO acts as a regulator of the expression of the platelet glycoprotein.