Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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DYNAMICS OF SEX HORMONES IN CHILDREN IN THE I-III STAGES OF SEXUAL DEVELOPMENT WITH CHRONIC INFLAMMATORY PATHOLOGY OF UPPER PARTS OF ALIMENTARY TRACT IN DEPENDENCE ON THE FACTOR OF HELICOBACTER PYLORI-INFECTION

Panova I.V. 1
1 Rostov state medical University
Conducted a study of sex hormones in the 77 children in the period of formation of puberty with chronic gastroduodenitis in conjunction with gastroesophageal reflux disease depending on the factor of Helicobacter pylori infection. Study of the level of hormones in the blood serum was carried out by means of immune-enzyme assay. Diagnosis of Helicobacter pylori was performed by polymerase chain reaction for the detection of DNA Нelicobacter pylori in biopsies antral mucosa of the stomach, urease method with the definition of for estimation of urease activity in biopsy of the mucous membrane of the stomach and immuno-analysis of blood serum for the presence of total antibodies to Helicobacter pylori. It is proved, that in children with Helicobacter pylori-associated pathologies estradiol level was above the test values. Testosterone levels in Helicobacter pylori-positive seropositive patients exceeded the control values and was higher than that of the Helicobacter pylori-positive seronegative patients. In children with Helicobacter pylori-associated gastroduodenitis much more often identified erosive forms of defeat mucous membrane of the stomach.