Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

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FEATURES IMMUNOGENETIC PROFILE RUSSIAN POPULATION CHELYABINSK REGION CHILDREN SUFFERING JUVENILE IDIOPATHIC ARTHRITIS

Pishchalnikov A.Y. 1 Volosnikov D.K. 1 Shilova T.V. 2 Suslova T.A. 3 Khromova E.B. 3 Kireeva G.N. 2
1  Chelyabinsk State Medical Academy
2  Regional Childrens Hospital
3  Chelyabinsk State University
The analysis of the distribution of genes and haplotypes of HLA I and II class was made for children of Russian nationality in Chelyabinsk region who suffering from juvenile idiopathic arthritis (JIA). A total number of patients with JIA is 67, where 22 children with systemic, 25 children with oligoarticular and 20 with polyarticular course of the disease. The control group included 207 healthy people of Russian nationality. Based on the evaluation criteria odds ratios (OR) identified positive associations of genes and haplotypes of HLA I and class II with the development of JIA. It is shown that the children of Russian nationality living in the Chelyabinsk region have the high risk of the disease. It associates with the presence of genes HLA-B*27, DRB1*08, DQA1*04:01, DQB1*04:02, and two-locus A*02 - B*27, *08-DQA1*04:01, DR*08-DQB*401/2, DQA * 401-DQB * 402 and three-locus DR*08-DQA*401 - DQB*401/2 haplotypes. In addition, it was identified the peculiarities of the frequency of gene HLA I and II classes occurrence, depending on the version of the current JIA.