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Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452
ISSN 2500-0780
ПИ №ФС77-57452
ACTIVITY OF OXIDATIVE PROCESSES IN LIVER MICROSOMES OF RATS WITH TOXIC DAMAGE BY ACETAMINOPHEN ACCORDING TO AGE
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The age-effects of acetaminophen on the activity of oxidative processes in liver microsomes were studied. Toxic damage to animals of 3 age periods - 3-month’s, 6-8-month’s and 18-24-month’s was caused by intraperitoneal injection of acetaminophen substance in dose of 1250 mg / kg (0,5 LD50) during 2 days. It was determined that acetaminophen shows the most evident inhibitory effect on the oxidative processes in liver microsomes of young animals, which is probably due to the high activity of the electron transport chains involved in the metabolic activation of acetaminophen. Slow normalization of indices in old animals may be a consequence of the prevalence of their covalent binding to cytochrome P -450, which leads to its irreversible inhibition and reduction of protein-synthetic processes due to the toxic effects on the chromosomes of hepatocytes.