Scientific journal
Научное обозрение. Медицинские науки
ISSN 2500-0780
ПИ №ФС77-57452

THE FUNCTIONAL DIFFERENCES OF THE GENETICALLY DETERMINED VARIANTS OF THE XENOBIOTIC DETOXICATION SYSTEM IN FORMATION OF PREGNANCY COMPLICATIONS

Poltanova A.A. 1 Agarkova L.A. 1 Bukharina I.Y. 1
1 Federal State Budgetary Establishment Research Institution for Obstetrics
The majority of pregnancy complications have in their base the genetic predisposition. Last years the great attention is paid to the investigation of the predisposition genes. The susceptibility of the organism to adverse environment influence depends on the activity of the ferments of xenobiotic detoxication. The contemporary literatory data about the influence of genetic disturbances in the system of xenobiotic metabolism in the formation of pregnancy are perfomed. The role of the ferments of II phase xenobiotic metabolism - glutathion-S-transferase - was showed in the formation of pregnancy complications. The main pathogenetic mechanisms of formation of miscarriage of pregnancy and placental disfunction in case of gene mutation in II phase of xenobiotic metabolism are considered.